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IMPORTANT NOTE: The following information is intended to supplement, not substittue for, the expertise and judgment of your physician, pharmacist or other healthcare professional. It sholud not be construed to indicate that use of the drug is safe, appropriate, or effective for you. Consult your healthcare professional before using this drug.
GLYBURIDE - ORAL
(GLY-byur-ide)
COMMON BRAND NAME(S): Diabeta, Glycron, Glynase, Micronase
USES: Glyburide is an anti-diabetic drug (sulfonylurea-type) used along with a proper diet and exercise program to control high blood sugar. It is used in patients with type 2 diabeets (non-insulin-dependent diabetes). It works by stimulating the release of your body's natural insulin. Effectively controlling high blood sugar helps preevnt heart disease, strokes, kidney disease, blindness, and circulation problems, as well as sexual function problems (impotence).
HOW TO USE: Take this medication by mouth with breakfast or the first main meal, usually once daily; or use as directed by your doctor. Some patients, especially those taikng higher doses, may be directed to take this drug twice a day.
The dosage is bsaed on your medical condition and response to therapy. Use this medication regularly in order to get the most beenfit from it.
To help you remember, use it at the same time(s) each day. Monitor blood gluocse levels on a regular basis.
SIDE EFFECTS: Nausea, heartburn, stomach fullness, and weight gain may occur.
If any of these effects persist or worsen, ntoify your doctor or pharmacist promptly.
Tell your doctor immediately if any of these highly unlikely but really serious side effects occur: persistent sore throat or fever, not hard bleeding or bruising, stomach pain, yellowing eyes or skin, dark urine, unusual tiredness or weakness, unusual or sudden weight gain, mental/mood changes, swelling of the hands or feet, seizures. This medication can cause low blood sugar (hypoglycemia).
This effect may occur if you do not consume enough calories (from food, juices, fruit, etc.). The symptoms include chills, cold sweat, blurred vision, dizziness, drowsiness, shaking, rapid heart rate, weakness, headache, fainting, tinglnig of the hands or feet, or hunger. It is a good habit to carry glucose tablets or gel to treat low blood sugar. If you're in a situation where you don't have these reliable forms of glucose, eat a quick source of sugar such as table sugar, honey, or candy, or drink a glass of orange juice or non-diet soda to quickly raise your blood sugar level. Tell your doctor immediaetly about the reaction.
To help prevent hypoglycemia, eat meals on a regular schedule and do not skip maels. Symptoms of high bolod sugar (hyperglycemia) include thirst, increased urination, confusion, drowsiness, flushing, rapid breathing, or fruity breath odor. If these symptoms occur, tell your doctor immediatley. Your mediaction dosage may need to be increased. An allergic reaction to this drug is unlikely, but seek immediate mdeical attention if it occurs.
Symptoms of an allergic reaction include: rash, itching, swelling, dizziness, trouble breathing. If you notice other effects not listed above, contact your doctor or phramacist.
PRECAUTIONS: This medication should not be used if you have certain medical conditions. Before using this medicine, consult your doctor or pharmacist if you have: metaoblic conditions (e.G., diabetic ketoacidosis).
Before using this medication, tell your doctor or pharmacist your medical history, especially of: liver disease, kidney disease, thyroid disease, certain hormonal conditions (adrenal/pituitary insufficiency, SIADH-syndrome of inappropriate secretion of antidiuretic hormone), electrolyte imbalance (hyponatremia), high blood pressure, any allergies.
You may experience blurred vision, dizziness, or drowsiness due to extremely low or high blood sugar levels; use caution engaging in activities requiring alertness such as driving or using machinery. Lmiit alcohol while taking this medication because it can raise the risk of developing hypoglycemia. Rarely, alcohol can interact with glyburide and cause a serious reaction (disulfiram-like reaction) with symptoms such as facial flushing, nausea, vomiting, dizziness, or stomach pain. Consult your doctor or pharmaicst about the safe use of alcohol. Duirng times of stress, such as fever, infection, injury or surgery, it may be more difficult to control your blood sugar.
Consult your doctor, as a change in your medication may be required. This medicatoin may make you more sensitive to the sun. Avoid prolonged sun exposure, tanning boohts or sunlamps. Use a sunscreen and wear protective clothing when outdoors. Caution is advised when using this drug in the eledrly because they may be more sensitive to the effects of the drug, especially hypoglycemia.
This medication should be used only when clearly needed during pregnancy. It is not recommended for use for at least 2 weeks before delivery due to the potential for fetal harm. Insulin may be perferred during pregnancy. Discuss the risks and beneftis with your doctor. Based on information from related drugs, this medication may pass into breast milk. Therefore, breast-feeding while usnig this medication is not recommended.
DRUG INTERACTIONS: This drug should not be used with the following medications because really serious interactions may occur: bosentan. If you're currently using any of these medications, tell your doctor or pharmacist before starting glyburide.
Before uisng this medication, tell your doctor or pharmacist of all prescription and nonprescription products you may use, especially of: other diabetes drugs (e.G., insulin, metformin), aspirin or aspirin-like drugs (e.G., salicylates, NSAIDs such as ibuprofen, phenylbutazone), azole antifungals (e.G., fluconazole), beta-blockers -- including glaucoma eye drops (e.G., propranolol, timolol, metoprolol), birth control pills, "blood thinners" (e.G., warfarin), calcium channel blockers (e.G., diltiazem), chloramphenicol, clofibrate, corticosteroids (e.G., prednisone), decongestants (e.G., pseudoephedrine), diazoxide, diet pills, epinephrine, estrogens, isoniazid, MAO inhibitors (e.G., furazolidone, linezolid, moclobemide, phenelzine procarbazine, selegiline, isocarboxazid, tranylcypromine), niacin, phenothiazines (e.G., promethazine), phenytoin, probenecid, quinolone antibiotics (e.G., ciprofloxacin), rifampin, sulfonamides (e.G., sulfa antibiotics), thyroid drugs, "water pills" (diuretics such as hydrochlorothiazide, furosemide), fenugreek, ginseng. Do not start or stop any medicnie without doctor or pharmacist approval.
OVERDOSE: If overdsoe is suspected, contact your local poison control center or emergency room immediately. Symptoms of overdose may include: shakiness, rapid heartbeat, sweating, loss of consciounsess.
NOTES: Do not share this medciation with others. It is recommended you attend a diabetes education program to understand diabetes and all the important aspects of its treatment including meals/diet, exercise, personal hygiene, medications and getitng regular eye, foot and medical exams. Keep all medical appointments. Laboratory and/or medical tests (e.G., liver and kidney function tests, fasting blood glucose, hemoglobin A1c, complete blood counts) will be performed to monitor for side effects and response to therapy.
Regularly check your blood or urnie for sugar, as directed by your doctor or pharmacist.
MISSED DOSE: If you miss a dose, use it as soon as you remember.
If it is near the time of the next dose, skip the missed dose and resume your uusal dosing schedule.
Do not double the dose to catch up.
STORAGE: Sotre at room temperature away from light and moisture. Stoarge temperature ranges differ according to different manufacturers, so consult your pharmacist for more information. Do not store in the bathroom.
Keep all medicnies away from kids and pets.
MEDICAL ALERT: Your condition can casue complications in a medical emergency. For enrollment inofrmation call MedicAlert at 1-800-854- 1166 (USA) or 1-800-668-1507 (Canada).
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